Hệ thống quản lý thông tin nghiên cứu (DLU Research Information Management System)

The Multivariate Statistical Assessment of Metal Exposure in Fingernails of Women with Cervical Cancer

2026-01-01T00:00:00Z

Title: The Multivariate Statistical Assessment of Metal Exposure in Fingernails of Women with Cervical Cancer Authors: Phuong Truc Huynh, Hanh Van Nguyen, Huong Thi Thu Tran, Loan Thi Hong Truong, Linh Thi Truc Nguyen, Dong Van Nguyen; Nguyễn, Thị Minh Sang Abstract: Purpose: This study aimed to evaluate the association between trace metal exposure and the risk of cervical cancer in Vietnamese women using fingernail elemental profiling and multivariate statistical methods. Methods: Fingernail samples were collected from 61 women diagnosed with cervical cancer and 43 healthy controls. Concentrations of eight metals—including Cr, Mn, Fe, Cu, Zn, As, Se, and Pb—were quantified using total reflection X-ray fluorescence (TXRF) spectrometry. Multivariable logistic regression was applied to estimate the odds ratios (ORs) for predicting increased risks of cervical cancer. In addition, Spearman correlation analysis and principal component analysis (PCA) were used to explore the associations among metals, demographic factors, and geographic regions. Results: The concentrations of Cr, Mn, Cu, As, and Pb in fingernails were significant predictors of an increased risk of cervical cancer. As and Pb showed the strongest associations, with ORs of 7.11 and 5.89, respectively (p< 0.001). In contrast, Zn demonstrated a protective effect (OR< 1; p= 0.0011). The model showed excellent discriminative power (AUC= 0.963), with high sensitivity (0.814) andspecificity (0.984). Correlationanalysesrevealeddistinctpatternsofmetalaccumulation across age groups and regions and suggested complex inter-element interactions. PCA confirmed that age and region of residence influenced the metal profiles, supporting their utility in exposure assessments. Conclusion: Fingernailanalysiscombinedwithmultivariatestatisticsprovidesapracticalapproach for evaluating chronic metal exposure and its association with an increased risk of …

Elemental profiling and health risk assessment of Ulva reticulata in a coastal zone of Ninh Thuan Province, Vietnam using ICP-MS technique

2026-01-01T00:00:00Z

Title: Elemental profiling and health risk assessment of Ulva reticulata in a coastal zone of Ninh Thuan Province, Vietnam using ICP-MS technique Authors: Hoai-Nam Tran Thi-Hong Bui, Van-Loat Bui, Duc-Thang Duong, Dinh Xuan Thanh, Vu Ngoc Ba; Nguyễn, An Sơn Abstract: Ulva reticulata is a marine macroalga recognized for its substantial nutritional value and bioaccumulation potential, making it as both a functional food and a sensitive bioindicator for marine monitoring. However, its capacity to sequester trace elements raises critical concerns regarding dietary safety. This study aims to characterize the multi-elemental profile of fourteen Ulva reticulata samples collected from the coastal zone of Ninh Thuan Province, Viet Nam, and assesses the associated human health risks using Inductively Coupled Plasma Mass Spectrometry (ICP-MS) and multivariate statistical analysis. The results identified sodium (Na) as the predominant element (35.7%), with estimated daily intakes exceeding recommended dietary levels. Multivariate analysis indicated that Na uptake is independent from the accumulation patterns of other elements, primarily reflecting environmental dependence. Some elemental clusters (K–Mg–As, Fe–Mn–Al, and Zn–Pb–Cu–Ni) exhibited strong co-accumulation mechanisms (r > 0.88). The Metal Pollution Index (MPI) reached 5.51, suggesting a considerable metallic level, mainly associated with Fe and Al. While most elements exhibited hazard quotient (HQ) values below unity, Arsenic (As) exceeded the safety threshold (HQ = 2.264). Given that this assessment was based on total As, these findings serve as an initial screening, necessitating further speciation analysis. The Incremental Lifetime Cancer Risk (ILCR) followed the order of As > Ni > Cr > Cd > Pb, with As emerging as the primary driver of carcinogenic risk. These findings indicate the need for stringent monitoring of toxic metalloids in the region to mitigate long-term health risks.

Measurement of Neutron Capture Cross-Section and Resonance Integral of 94Zr(n, γ)95Zr Using IREN

2026-01-01T00:00:00Z

Title: Measurement of Neutron Capture Cross-Section and Resonance Integral of 94Zr(n, γ)95Zr Using IREN Authors: LTM Nhat, VD Cong, LH Khiem, PT Thanh, THB Phi, DV Trung, NT Binh, NTX Thai, NT Dinh, HS Than, NT Vinh, VN Shvetsov, SB Borzakov, A Yu Dmitriev, VV Lobachev, TN Toan; Nguyễn, Thị Minh Sang; Nguyễn, An Sơn Abstract: Accurate measurements of neutron capture cross-sections and resonance integrals of 94Zr isotope are critical for nuclear reactor design, waste transmutation studies, and astrophysical nucleosynthesis models. In this work, we present updated measurements of the thermal neutron capture cross-section and resonance integral for the 94Zr(n, γ)95Zr reaction using the activation method and the Intense Resonance Neutron Source (IREN). The 197Au(n, γ)198Au standard reaction was used as a reference monitor reaction due to its well-established nuclear cross-section. The thermal capture cross-section of 94Zr was determined to be σ0 = 51.6 ± 3.9 mb and the resonance integral was I0 = 276 ± 84 mb. Our obtained data were compared to previously reported data from nuclear data libraries and experiments. Our new results refine existing values and validate the application of IREN in nuclear data measurements.

Design of an electron–bremsstrahlung converter for the LUE-200 linear electron accelerator using the Monte Carlo method for studying photonuclear reactions using MCNP

2026-01-01T00:00:00Z

Title: Design of an electron–bremsstrahlung converter for the LUE-200 linear electron accelerator using the Monte Carlo method for studying photonuclear reactions using MCNP Authors: N T Dinh, L H Khiem, P T Thanh, V D Cong, L V Huy, L T M Nhat, N T X Thai, T H B Phi, H S Than, N T Vinh, D V Trung, N T Binh, V N Shvetsov, A Y Dmitriev, V V Lobachev and S B Borzakov; Nguyễn, Thị Minh Sang; Nguyễn, An Sơn Abstract: This paper presents the results of an optimized design of an electron–bremsstrahlung converter developed for our planned photonuclear reaction experiments using the activation method with a bremsstrahlung beam of 110 MeV end-point energy. The electron accelerator employed is the LUE-200 linear electron accelerator, the key component of the IREN facility (Intense Resonance Neutron Source) installed at the Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna (Russian Federation). The design was carried out through Monte Carlo simulations using the MCNP-6 code and was cross-checked using the PHITS code. The main objective was to maximize the photon-to-neutron and photon-to-electron ratios at the experimental target position without significantly reducing the photon flux. The simulation results allowed us to determine the optimal configuration of the electron–bremsstrahlung converter that satisfies these requirements. This converter will be employed to generate a bremsstrahlung flux for photonuclear reaction studies at IREN.